Determination of BIS50 and ED50 for propofol during induction by sequential experimental method
- VernacularTitle:序贯试验法测定异丙酚诱导时的BIS50和ED50
- Author:
Xing XU
;
Xiulan WEI
;
Xinmin WU
- Publication Type:Journal Article
- From:
Chinese Journal of Anesthesiology
2001;21(1):7-9
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo determine the bispectral index and dose of propofol at which 50 % of patients fall into unconsciousness during induction (BIS50 and EDs0 ). MethodsThirty unpremedicated ASA Ⅰ-Ⅱ patients scheduled for elective surgery were included in this study. The patients did not take any sedatives or hypnotics and had no psychiatric disease. Loss of consciousness and changes in BIS during induction with propofol were studied by sequential experimental method. The loss of responses to verbal command and eyelash stimulation was used as an induction of unconsciousness. The data obtained were analyzed by linear regression and calculated to determine BIS50 and ED50 using weighted averaging method. ResultsThe BIS50 and ED50 for propofol were 79.17 and 1.0192 ng/kg with the 95％ confidence intervals of 72.08-88.55 and 0.94-1.148 mg/kg respectively. Conclusions The sequential experimental method for determination of ED50 is simple, efficient and reliable and also suitable for determination of BIS50.
