Effects of UVB and UV-irradiated UCA on the Function of Langerhans＇ Cell
- VernacularTitle:紫外线及其辐射的尿刊酸对朗格汉斯细胞功能影响的研究
- Author:
Yanhua LI
;
Zhigang BI
;
Yi JIANG
- Publication Type:Journal Article
- From:
Chinese Journal of Dermatology
2001;34(1):47-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the immunosuppression mechanism induced by ultraviolet (UV) and cis-urocanic acid. Method The auto lymphocyte proliferation test with Langerhans＇ cell (LC) in guinea -pig was performed. Results In exposure to low dose of UVB (25 J/m2) radiation, the inhibition rate of lymphocyte proliferation stimulated by LC was 10. 5%, the inhibition rates of UVB radiation in doses of 50 J/m2 and 100 J/m2 were 22.4% or 50%, respectively. The lymphocyte proliferation was almost completely suppressed by200J/m2 UVB radiation, while the inhibition of LC function by cis-urocanic acid was weak. Conclusion UVB significantly inhibits LC auto -stimulation in dose -dependent way, which may play an important role in UVB induced immunosuppression.
