Preliminary Study on Anticyclophilin A Auto-Antibodies in Sera of Patients with Psoriasis
- VernacularTitle:银屑病患者血清中抗亲环素A自身抗体的初步研究
- Author:
Xin SHEN
;
Xinzhong FENG
- Publication Type:Journal Article
- From:
Chinese Journal of Dermatology
2001;34(2):93-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the level of anticyclophilin A auto-antibodies (ACA) in sera of patients with psoriasis. Methods Cyclophilin A (CyPA) was extracted and purified from bovine thymus. The level of anticyclophilin A auto-antibodies (ACA) was detected by enzyme-linked immunosorbent assay (ELISA) and immunoblotting test (IBT) in sera of patients with psoriasis. Results It was shown that the level of ACA was significantly higher in the sera of patients with psoriasis than those in control group (IBT:P<0.01,ELISA:P< 0.01). ACA was found to be positive in 41.3％ of the patients by ELISA. In psoriatic group, the serum level of ACA was higher during the progressive stage than that in the stationary stage, however, no significant difference was observed (IBT:P>0.05,ELISA:P >0.05). Conclusion The results suggest that there is autoimmunological mechanism in the pathogenesis of psoriasis.
