The detection of postoperative hematogenous dissemination of colorectal cancer
- VernacularTitle:大肠癌术后血路播散的动态追踪监测
- Author:
Chengyu LUO
;
Shiyong LI
;
Danning ZHAO
- Publication Type:Journal Article
- From:
Chinese Journal of General Surgery
2001;16(2):118-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance of monitoring postoperative hematogenous micrometastasis of colorectal cancer． Methods The micrometastatic cancer cells in peripheral blood and bone marrow of the perioperative patients were investigated by CK20 mRNA RT-PCR. Results The positive rates(16.3%) of hematogenous dissemination without relapse or metastasis after operation were significantly lower than that(88.9%) in patients with postoperative relapse or metastasis. There were four types of hematogenous dissemination. (1) Postoperative temporary negatives.(2)Consistant positives. (3) CK-20 turned positive postoperatively. (4) Consistant negatives. All the 6 patients that died had positive CK-20 preoperatively. Conclusions The hematogenous dissemination of colorectal cancer plays an important role in postoperative relapse. The dynamic monitoring of CK-20 predicts hematogenous dissemination of colorectal cancer.
