Relationship between p53 mutation and survival in patients with liver metastasis of colorectal cancer after hepatectomy
- VernacularTitle:p53变异与结肠癌肝转移肝部分切除术后病人生存期的关系
- Author:
Yang YANG
;
Rongcheng LUO
;
Hang ZHENG
- Publication Type:Journal Article
- From:
Chinese Journal of Hepatobiliary Surgery
2001;7(1):24-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate dynamic changes of the p53 gene and its protein during occurrence and metastasis of colorectal cancer and explore the relationship between p53 mutation and survival of the patients. Methods p53 gene (exon 5-9) was examined by PCR, denaturing gradient gel electrophoresis (DGGE) and automated sequencing. Results p53 alterations were found in exons 5 through 9 in 26 of the 41 patients (63%). Of the 26 patients, 6 had the alterations in the liver metastatic lesions but not in the original colorectal lesion. The other 20 had the alterations in both of the primary colorectal and hepatic metastatic lesions. Meanwhile, an additional mutation in the metastatic lesions was found in 3 cases. The analysis about the survival revealed that the patients with mutant p53 in the metastatic lesions had a longer survival as compared with those with wild type p53. Conclusion In the process of liver metastasis of the colorectal cancer, p53 mutations mainly start in the primary colorectal lesion and then is kept and brought into the liver. It also might start from metastatic lesion in a few cases. For the patients who had liver metastasis of colorectal cancer and underwent hepatectomy, the survival is longer in mutant p53 group than in wild type p53 group.
