Correlationship between proliferating cell nuclear antigen, intercapillary distance and radiosensivity in uterine cervical cancer
- VernacularTitle:增殖细胞核抗原和毛细血管间距与宫颈癌放射敏感性的关系
- Author:
Jiandong WANG
;
Juzhen GAO
;
Weizh YANG
- Publication Type:Journal Article
- From:
Chinese Journal of Radiation Oncology
2001;10(2):122-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlationship between proliferating cell nuclear antigen (PCNA), intercapillary distance (ICD) and radiosensitivity in uterine cervical cancer. Methods 112 patients who received radiotherapy alone were followed over five years. All PCNA expressions and ICD values were analyzed with immunohistochemistry assay and computer-defined capillary images. Results PCNA expression was observed in all patients with the average index of 0.542 ranging from 0.241 to 0.903 um. ICD averaged 180.42 um (ranging from 58.47 to 243.62 um). Conclusions The PCNA expression and ICD value, being closely correlated with radiosensitivity and response to therapy, can be useful as markers for prediction and selection of treatment decision for uterine cervical cancer.
