Effect of morphine dependence on nucleic metabolism in hippocampal neurons in mice
- VernacularTitle:吗啡依赖对小鼠海马神经元核酸代谢的影响
- Author:
Yinguo ZHANG
;
Jisheng LI
;
Jie WEI
- Publication Type:Journal Article
- From:Chinese Journal of Behavioral Medicine and Brain Science
2001;10(2):87-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the molecular mechanism about injurious effect of morphine dependence on the construction and function of hippocampal neurons. Method Mice were given (sc) increasing doses of morphine to form morphine-dependence model ,and the DNA and RNA changes stained with acridine orange (AO) fluorescence probe technique were investigated in hippocampal neurons of morphine-dependence group,naloxone-precipitated withdrawal group in morphine-dependence mice and control group. Results Compared with control group , the staining changes of DNA,RNA decreased obviously in hippocampal neurons of both morphine-dependence group and naloxone- precipitated withdrawal group in morphine-dependence mice,especially the later. Conclusion Both morphine-dependence and naloxone-precipitated withdrawal in morphine-dependence mice injured nucleic acid metabolism in hippocampal neurons ,especially the later.Those changes may be some reasons of decreased brain function ,especially in learning and memory deficits.
