Progress of mechanisms in cerebral palsy caused by intrauterine infection
10.3760/cma.j.issn.1673-4408.2011.02.004
- VernacularTitle:宫内感染致脑性瘫痪的机制研究进展
- Author:
Yang YANG
- Publication Type:Journal Article
- Keywords:
Cerebral palsy;
Intrauterine infection;
Inflammatory cytokines;
Nervous factors;
Gene mutation/deletion
- From:
International Journal of Pediatrics
2011;38(2):108-110
- CountryChina
- Language:Chinese
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Abstract:
In recent years, many studies have claimed that the intrauterine infection is one of the most common causes of cerebral palsy. Cerebral palsy is associated with the brain injury directly or indirectly. With the direct mechanisms including breakdown of infected nerve cells of the mouse by intrauterine infection,hydrocephalus, dilation of the cerebral ventricles and ependymitis being illuminated uninterruptedly, researches of the indirect mechanism in cerebral palsy caused by intrauterine infection become the hot issue in the domain.Besides the inflammation mediators theory and down-regulated expression of development of the nervous system related factors, there were still several important elements which can cause brain damage such as placental excretive hormone imbalance, change of activity of Notch signaling and gene mutation/deletion and so on.Mechanisms and the interaction between them built up network effect.
