Effects of subconvulsive electrical stimulations to hippocampus on rat's emotional behaviors and spatial learning and memory
- VernacularTitle:海马惊厥阈下电刺激对大鼠情感行为及空间学习记忆的影响
- Author:
Qingsong WANG
;
Ru ZHANG
- Publication Type:Journal Article
- From:Chinese Journal of Behavioral Medicine and Brain Science
2001;10(3):161-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of repeated subconvulsive electrical stimulations to hippocampus on rat's emotional behavior and spatial learning and memory. Mehtods The hippocampus of Wistar rats were repeatedly stimulated by constant pulsating current with intratrain frequencies of 16 Hz, pulsating duration of 1 ms, train duration of 10 s and interstimulus interval of 7 min for 5 days. Results The experimental rats displayed the long-term significant abnormalities of emotional behaviors, such as substantial changes of behavioral habits, hyperarousal, hypersensitive frightened reactions, anxiety-like behaviors, and transitory spatial learning and memory disorder. Conclusion The stable and practical animal model satisfied most characteristics of posttraumatic stress disorder (PTSD).
