Progress of Th17
10.3760/cma.j.issn.1673-4408.2011.02.027
- VernacularTitle:Th17细胞研究进展
- Author:
Min WANG
- Publication Type:Journal Article
- Keywords:
CD4+ T cells;
Th17;
Interleukin-17
- From:
International Journal of Pediatrics
2011;38(2):181-185
- CountryChina
- Language:Chinese
-
Abstract:
T helper 17 cells (Th17), a new type of CD4 + T cells, constitute the main subsets of CD4 +T cells together with Th1, Th2 and Treg. Some factors, such as the combination of interleukin (IL) 6 and transforming growth factor β, orphan nuclear receptor-γt, signal transducer and activator of transcription 3 are involved in the differentiation of the Th17. The differentiation process can be precisely regulated on cellular and molecular levels. It produces IL-17, IL-22, and IL-6, and plays a significant role in autoimmunity, infectious and transplant rejection. Therefore, Th17 and its related cytokines may provide promising targets and approaches for the treatment of diseases.
