Complication of Intraoperative Radiation Therapy (IORT) in Gastric Cancer.
- Author:
Myung Se KIM
1
;
Sung Kyu KIM
;
Sung Kyo SONG
;
Hong Jin KIM
;
Koing Bo KWAN
;
Heung Dae KIM
Author Information
1. Department of Therapeutic Radiology, Yeungnam University College of Medicine, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
IORT;
Gastric Cancer;
Complication;
External irradiation;
Chemotherapy
- MeSH:
Academic Medical Centers;
Bone Marrow;
Depression;
Drug Therapy;
Follow-Up Studies;
Hemorrhage;
Humans;
Neoplasm Metastasis;
Radiation Oncology;
Sepsis;
Stomach Neoplasms*
- From:Journal of the Korean Society for Therapeutic Radiology
1992;10(2):187-192
- CountryRepublic of Korea
- Language:English
-
Abstract:
Local control is the important prognostic factor in cancer treatment because local control decrease the relative risk of metastatic spread and increse distant metastasis free survival. IORT is the modality which could increase local control without incressing complication, combined with curative operation. Eventhough we could achieve significant deacreased local failure by IORT and curative resection, it should not be committed as a main treatment modality without proving acceptable complications. Therapeutic Radiology Department of Yeungnam University Medical Center have tried 58 IORT from June 15, 1988, and performed 53 IORT in patients with gastric cancer. No local failure has been reporte? by regular follow up so far. Nine cases(17%) of treatment related complifaiton were reported including intestinal obstrution, hemorrhage, sepsis, and bone marrow depression. These complications could be comparable to Jo's 25.2% (chemotherapy + operation), Kim's 18% (chemotherapy only in inoperable patients), because our treatment regimen is consisted of IORT (1500 cGy), external irradiation(--4500 cGy) and extensive chemotherapy (FAM, 5FU+MMC, BACOP). Our data encouraged us to re-inforce further IORT in stomach cancer treatment.
