MicroRNA and preoperative diagnosis of papillary thyroid carcinoma
10.3760/cma.j.issn.1673-422X.2011.03.013
- VernacularTitle:微RNA与甲状腺乳头状癌术前诊断
- Author:
Peishun WANG
;
Honghao LI
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Thyroid neoplasms
- From:
Journal of International Oncology
2011;38(3):200-202
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs(miRNAs)are a class of small noncoding RNA molecules that function as posttranscriptional gene regulators by base-pairing with their target mRNAs where they either repress translation or direct destructive cleavage.Recent evidences have shown that miRNAs were aberrantly expressed in papillary thyroid carcinoma(PTC)compared with normal thyroid tissue,indicating that they may play a crucial role in the initiation and progression of PTC.Some deregulated miRNAs might potentially be adjunct markers in the preoperative diagnosis of papillary thyroid carcinoma.
