The change of plasma von willebrand factor and endothelin levels in patients with pregnancy induced hypertension
- VernacularTitle:妊娠高血压综合征患者血浆血管性假血友病因子及内皮素水平的变化
- Author:
Chenhong WANG
;
Liping JIN
;
Jianlin CHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Obstetrics and Gynecology
2001;36(4):212-214
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of plasma von willebrand factor (vWF) and endothelin-1(ET-1) levels in patients with pregnancy induced hypertension (PIH). Methods Plasma vWF and ET-1 were studied by ELISA method and immunoradiological method respectively in 36 patients with PIH, 18 normal pregnant women and 19 normal non-pregnant women. Results Circulation levels of vWF and ET-1 were increased with increasing severity of the PIH. In mild PIH patients, the levels of plasma vWF ［(135.9±30.9)%, （P>0.05)］ weren′t significantly higher than those in healthy pregnant women ［(131.6±39.2)%,（P>0.05)］，but the levels of ET-1 ［(63.7±4.8) pg/L］ were significantly higher than those in healthy pregnant women ［(47.1±4.7) pg/L,（P<0.01)］. There were significant differences between groups of moderate-severe PIH ［vWF (174.4±35.4)%, ET-1 (92.6±19.1) pg/L］. There was a positive correlation between the plasma vWF level and ET-1 level. Conclusion The results suggested that plasma vWF and ET-1 concentration could be used as indicators for the severity of PIH.
