Influence of Aspirin on Plasma Levels of Lysophosphatidic Acid in Patients with Ischemic Cerebrovascular Diseases
- VernacularTitle:阿司匹林对缺血性脑血管病患者血浆溶血磷脂酸含量的影响
- Author:
Zhenguang LI
;
Qizhuan WU
;
Zhancai YU
;
Cunshan YAO
;
Chaoshu TANG
;
Yuanchen WANG
;
Lei SHAO
- Publication Type:Journal Article
- Keywords:
lysophosphatidic acid;
ischemic cerebrovascular diseases;
aspirin;
platelet
- From:
International Journal of Cerebrovascular Diseases
2005;13(2):102-105
- CountryChina
- Language:Chinese
-
Abstract:
To observe whether plasma levels of lysophosphatidic acid (LPA) can be decreased in patients with cerebrovascular diseases after the treatment with aspirin. Methods:A total of 1,400 patients were recruited. Among them,803 patients were diagnosed as probable ischemic stroke,and 343 patients were diagnosed as ischemic stroke. Thirty-four health volunteers were used as control subjects. The levels of LPA were measured by chromatography with the combination of inorganic phosphorus quantitative method. Results: The levels of LPA in the ischemic cerebrovascular group (3.11 ± 1.55 μmol/L) were significantly higher than those in the control group (1.77 ± 1.04 μmol/L) (P < 0.001). Taking aspirin (80 mg,qd) for one month significantly decreased the levels of LPA. After stopping aspirin for one month,the level of LPA re-elevated (3.90 ± 1.09 μmol/L),was higher than that during administration of aspirin (1.93 ±0.85 μmol/L(P <0.001). Conclusions: There are close correlations between the increased levels of LPA and the platelet activation. Aspirin decreases the level of plasma LPA;this may be one of the mechanisms of aspirin in prevention against ischemic stroke.
