Effect of nerve growth factor on the pathogenesis of bronchial asthma
10.3760/cma.j.issn.1673-4408.2011.02.018
- VernacularTitle:神经生长因子在支气管哮喘发病机制中的作用
- Author:
Yungang YANG
- Publication Type:Journal Article
- Keywords:
Nerve growth factor;
Bronchial asthma;
Airway inflammation;
Airway hyperresponsiveness;
Airway remodeling
- From:
International Journal of Pediatrics
2011;38(2):151-154
- CountryChina
- Language:Chinese
-
Abstract:
The nerve growth factor(NGF) belongs to the neurotrophin family, comes from many immune cells and lung resident cells, and regulates the functions of many immune cells. Recent studies suggest that NGF may play an important role in the pathogenesis of bronchial asthma. In this review, we will provide information about NGF in the airways, describe its expression and regulation, and point out its potential role in inflammation,hyperresponsiveness, and remodelling process observed in asthma.
