Experimental study on arsenic trioxide and fluorouracin, gemcitabine effects on human pancreatic carcinoma cell lines PC-3
10.3760/cma.j.issn.1008-6706.2010.s1.001
- VernacularTitle:三氧化二砷与氟尿嘧啶、吉西他滨对胰腺癌细胞作用的对照研究
- Author:
Gaojian CAO
;
Ruiyao ZHOU
;
Zhenfeng HUANG
;
Qiang LI
;
Shengzhang LIN
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide;
Fluorouracil;
Gemcitabine;
Pancreatic neoplasms
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(z1):1-2
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of arsenic trioxide ( As2 O3 ) on inhibiting the proliferation of pancreatic carcinoma cell lines. Methods The inhibiting rate of As2O3 and Fluorouracin(5-Fu) ,Gemcitabine(GEM) on pancreatic carcinoma cell lines PC-3 were detected by using CCK-8 assay. Results As compared with 5-Fu、GEM,the inhibiting rate of As2O3 was the highest one( P ＜ 0.01 or P ＜ 0.05). Conclusion As2O3 can inhibit pancreatic carcinoma cell lines PC-3 effectively in vitro. The effects of As2O3 on inhibiting the proliferation of pancreatic carcinoma cell lines was stronger than 5-Fu and GEM. This is possibly due to the extensive and unique anticancer mechanism of As2O3.
