EFFECT OF PROSTAGLANDIN E1 ON SIL-6R and ITSβ strands IN SERUM IN PATIENTS WITH CHRONIC SEVERE HEPATITIS
- VernacularTitle:前列腺素E1对慢性重型肝炎患者血清可溶性白细胞介素-6受体及其β链的影响
- Author:
Bingxi ZHOU
;
Xiufeng NIU
;
Jia SHANG
;
Yukui LI
- Publication Type:Journal Article
- From:
Chinese Journal of Postgraduates of Medicine
2001;24(6):16-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of prostaglandin E1 on soluble interleukin-6 receptor(SIL-6R) and soluble interleukin-6 receptor β strands (sgp 130) in serum in patients with chronic severe hepatitis.Methods Sixteen patients with chronic severe hepatitis accepted therapy with prostaglandin E1.Serum levels of SIL-6R and sgp130 were detected by enzyme linked immunosorbent assay (ELISA) method before and after therapy.Results The content of SIL-6R and sgp 130 in serum were increased significantly (P<0.001) in patients with chronic severe hepatitis compared with normal control group and decreased obviously (P<0.01) after therapy with prostaglandin E1 compared with before therapy,and the rate of delth were decreased obviously (P<0.01) in PGE1 therapy group.Conclusion The levels of SIL-6R and sgp130 in serum can reflect the degree of liver damage in patients with chronic severe hepatitis and guide the assessment of prognosis;PGE1 can correct the immune disorder,attenuating hepatocyte inflammation and necrosis.
