THE CHANGES AND SIGNIFICANCES OF PLATELET GMP-140 AND GMP-140 IN PLASMA IN PATIENTS WITH ACUTE CEREBRAL INFARCTION
- VernacularTitle:不同类型脑梗死急性期血小板功能变化研究
- Author:
Zhiyu NIE
;
Zhonghui ZHANG
;
Yue ZHENG
;
Ying LIU
;
Naichang WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Postgraduates of Medicine
2001;24(5):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes and significances of platelet granule membrane protein-140 (GMP-140),GMP-140 in plasma,PAdT and PAgT in patients with acute cerebral infarction.Methods The platelet GMP-140 was measured with enzyme-linked immunosorbent assay (ELISA) competitive method and GMP-140 in plasma by ELISA double antibody method in blood collecting in 3 d and 2 weeks after onset in large(n=22),small(n=25) size and lacuna (n=20) cerebral infarction groups.Results The platelet GMP-140,GMP-140 in plasma,PAdT and PAgT in large cerebral infarction group in 3 d after onset were much higher than control group (P<0.001),and the small size and lacuna groups were higher (P<0.05～0.001) than control but lower than large group (P<0.05).There was no differences between the small and lacuna groups (P>0.05).The PAdT and PAgT in 3 groups were higher (P<0.01).The platelet GMP-140 and GMP-140 in plasma in all 3 groups in 2 weeks after onset had been clearly lower but still higher than control group (P<0.05),the PAdT and PAgT were normal or even more lower.Conclusion Platelet activation was significant in different types acute cerebral infarction,the concentration of GMP-140 in plasma can reflect the degree of platelets activities more well and truly than PAdT and PAgT.
