Left ventricular diastolic dysfunction assessment by tissue Doppler imaging in a suprarenal abdominal aortic coarctation model of Lewis rat
- VernacularTitle:组织多普勒显像对肾上腹主动脉缩窄大鼠心脏形态及舒张功能的研究
- Author:
Weichun WU
;
Hao WANG
;
Fuqiang LIN
;
Zhe ZHENG
- Publication Type:Journal Article
- Keywords:
Echocardiography,Doppler;
Aorta,abdominal;
Ventricular function,left;
Rats,inbred Lew
- From:Chinese Journal of Ultrasonography
2008;17(3):250-253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the left ventricular diastolic dysfunction by tissue Doppler imaging (TDI)in a suprarenal abdominal aortic coarctation model of Lewis rats. Methods Thirty male Lewis rats at age of 8 weeks were used. Myocardial hypertrophy model was obtained by suprarenal abdominal aorta banding with ligation. Mitral annular velocity measurement by TDI and regular two-dimensional echocardiography with M mode were examined at baseline and at 10-,20-,30-and 40-day post banding.Results Compared with baseline,the left ventricular end diastolic and end systolic wall thickness and ventricular dimension were progressively increased,while ejection fraction(EF)and fraction shortening(FS)were decreased(P＜0.0 1).The left ventricle demonstrated centrifugal myocardial hypertrophy.Peak myocardial systolic velocity(Sa)at the mitral annulus did not change significantly throughout this study and there was no significant correlation with EF(r=0.216,P=0.071),and peak myocardial early diastolic (Ea),late diastolic(Aa)at the mitral annulus and Ea/Aa indices also were not stable after aortic banding and there were no significant difference in repeated measures at different time(P＞0.05).But the E/Ea wasincreased and the index had a statistically significant difference(P＜0.001).Conclusions The left ventricleshowed centrifugal myocardial hypertrophy in Lewis rats with abdominal aortic banding.E/Ea radio was a sensitive and stable index to evaluate left ventricular diastolic dysfunction.
