Effect of Astragalus on T Lymphocyte Immune Function in Immature Rats with Obstructive Jaundice
- VernacularTitle:黄芪对梗阻性黄疸幼鼠T淋巴细胞免疫功能的影响
- Author:
Zhaodong HAN
;
Yueqin RUAN
;
Lan ZHANG
;
Qizhong FAN
;
Tingliang FU
- Publication Type:Journal Article
- Keywords:
Astragalus;
Obstructive jaundice;
Cellular immunity;
Immature rats
- From:
International Journal of Traditional Chinese Medicine
2008;30(2):87-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of Astragalus on T lymphocyte immune function in peripheral blood and intestinal mucosa of immature rats with obstructive jaundice. Methods Three-week-old Wistar rats were randomly divided into four groups(n=12,in each):control group, sham operation group, obstructive jaundice(OJ)group,OJ+Astragalus (OJ+A)group.The percentage of CD4 and CD8 T lymphocytes, the ratio of CD4 to CD8 in peripheral blood and intestinal mucosa of immature rats was detected by flow cytometry. Result The percentage of CD4+ cell and the ratio of CD4 to CD8 in the OJ group were lower than those in the control group and the sham operation group,with significant difference(P＜0.05).The percentage of CD4 cell and the ratio of CD4 to CD8 in the OJ+A group were higher than those in the OJ group(P＜0.05).Conclusion Astragalus can increase T lymphocyte immune function in OJ immature rats.
