RNA Interference and its Applications in Cancer Therapy
- VernacularTitle:RNA干扰及其在癌症治疗中的应用
- Author:
Fuguo WU
;
Yirong CHEN
;
Xuechun WANG
;
Li CHENG
- Publication Type:Journal Article
- Keywords:
RNA interference;
RNA,small interfering;
MicroRNAs;
Neoplasms
- From:
Journal of International Oncology
2007;34(11):862-866
- CountryChina
- Language:Chinese
-
Abstract:
RNA interference(RNAi), a highly conserved process of post-transcriptional gene silencing, can be induced by small interfering double-stranded RNA that mediate sequence-specific mRNA degradation. In the past several years, RNAi has been widely used as both an experimental tool to study mammalian gene function and a potential therapeutic approach to treat human diseases. In addition, some new proteins which involve in RNAi pathway have been characterized in mammalian cells. Here, we summarize the various molecules in RNAi, mechanism of action, and the current therapeutic applications in cancers.
