Significance and detection of levels of IL-8,TNF-α in serum of patients with aplastic anemia
- VernacularTitle:再生障碍性贫血患者血清IL-8、TNF-α水平的检测及其意义
- Author:
Guizhen YANG
;
Ping YANG
- Publication Type:Journal Article
- Keywords:
Anemia,aplastic;
Interleukin-8;
Tumor necrosis factor-α
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(2):198-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of levels of IL-8,TNF-α in serum of patients with aplastic anemia(AA).Methods Serum levels of IL-8 and TNF-α in 45 patients and 30 normal controls were measured by enzyme linked immunosorbent assay.Results The serum levels of IL-8,TNF-α increased significantly in AA and acute AA(AAA)group than in the control group(P＜0.05),there was no statistical significance between chronic AA(CAA)group and the control group(P＜0.05),and the levels in AAA group were much higher than in CAA group(P＜0.05).The serum level of IL-8 was positively related to TNF-αin AA group(r=0.682,P＜0.05).Conclusion There are immunological disorders in patients with AA and the overproduction of IL-8,TNF-α might be involved in the immunopathogenesis of AA,AAA.
