Acarbose decreases the risk of recurrent stroke in impaired glucose tolerance patients with ischemic stroke
- VernacularTitle:阿卡波糖降低缺血性脑卒中合并葡萄糖耐量减低患者再发脑卒中风险的研究
- Author:
Hong WANG
;
Jinping LIU
;
Xiaochao ZHANG
- Publication Type:Journal Article
- Keywords:
Acarbose;
Glucose tolerance test;
Cerebrovascular accident;
Recurrence
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(10):20-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine wherher acarbose could decrease the risk of recurrent stroke in impaired glucose tolerance(IGT)patients with ischemic stroke.Methods Four hundred and sixteen patients with transient ischemic attack(TIA)or minor ischemic stroke were selected into this trial and participated 75g oral glucose tolerance test(OGTT)1 month after their diagnosis and recovery of the disease.One hundred and nineteen IGT patients were randomly divided into two groups.Patients in pharmaceutical intervention group were treated with acarhose while those in the observation group were not.Seventy patients were selected randomly in those patients without IGT(control group).All patients of the three groups were administered low dose aspirin.Results During 3 years follow-up,8 patients (13.33%)experienced a stroke in pharmaceutical intervention group.The risk of recurrent stroke was decreased significantly compared with that in observation group(P＜0.05),and there Was no significant difference between pharmaceutical intervention group and control group (P＞0.05). Conclusion Acarbose can degrade the risk of recurrent stroke in IGT patients with ischemic stroke.
