Applications of Bone Marrow Stromal Cells in Gene Therapy of Central Nervous System Diseases
- VernacularTitle:骨髓基质细胞在中枢神经系统疾病基因治疗中的应用
- Author:
Kun ZAN
;
Yonghai LIU
;
Chenghua XIAO
;
Zunsheng ZANG
;
Xia SHEN
- Publication Type:Journal Article
- Keywords:
bone marrow stromal cell;
gene therapy;
nervous system disease
- From:
International Journal of Cerebrovascular Diseases
2008;16(2):131-136
- CountryChina
- Language:Chinese
-
Abstract:
Gene therapy refers to the introduction of normal genes into human target cells for correcting gene defects or exerting therapeutic action,and thus achieves the goal of treatment of disease.Bone marrow stromal cells (BMSCs) are stem cells that possess self-renewal and multi-directional differentiation potential and easy to amplify in vitro,and they also express many therapeutic exogenous genes in vitro or in vivo.So BMSCs have been regarded as an ideal target cell of cell and gene therapy.This article reviews the biological characteristic of BMSCs,some commonly used gene therapy vectors and their applications in gene therapy of central nervous system diseases.
