The expression of HGF and c-Met in gastric carcinoma
- VernacularTitle:肝细胞生长因子和c-Met在胃癌组织中的表达及其意义
- Author:
Qinghua ZHAG
;
Jun BU
;
Kun QIAN
;
Langsong HAO
;
Xiaoting WU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Hepatocyte growth factor;
Pathology,clinical;
Neovasculariation,pathologic;
Lymphangiogenesis
- From:
Chinese Journal of General Surgery
2008;23(3):223-226
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between HGF/c-Met and biological behavior and prognosis of gastric carcinoma.Methods The expression of HGF.c-Met.microvessel density and microlymphatic densitv in 58 cases of gastric carcinoma and 27 cases of gastric ulcer were evaluated by immunohistochemistry，using monoclonal antibodies for HGF，c-Met，CD34 and Lyve-1 respectively.Results HGF and c-Met protein were overexpressed in gastric carcinoma，and were significantly higher than those in the mucosa of gastric ulcer(P＜0.01).The microvessel density and microlymphatic density of gastric carcinoma were significantlv different between those with and those without lymphatic metastasis and distant metastasis(all P＜0.05)：The positive expression of HGF and c-Met in those with lymph node metastasis(86％，80％)was significantly higher than those without lymph node metastasis(57％，36％)，P＜0.05.That with distant metastasis(100％.94％)was higher than that without(71％，60％)，P＜0.01.The 5 year survival rate in patients with positive HGF and c-Met expression was much lower than that with negative expression(P=0.019，P＜0.01)，Multivariate analysis indicated HGF and c-Met expression，depth of invasion.lymph node metastasis.distant metastasis，microvessel density and microlymphatic density were all independent prognostic factors of gastric carcinoma.ConclusionsExpression of HGF and c-Met closely correlated with carcinogenesis，development and prognosis of gastric carcinoma.
