Study on treatment of dopamine extravasation-induced injury by lidocaine combining dexametha sone
- VernacularTitle:利多卡因联合地塞米松治疗多巴胺外渗损伤的研究
- Author:
Lianshan TAO
;
Yun LIU
;
Guimei WU
;
Liping PAN
;
Ping ZHANG
- Publication Type:Journal Article
- Keywords:
Lidocaine;
Dexamethasone;
Dopamine;
Drug extravasation;
Animal
- From:
Chinese Journal of Practical Nursing
2008;24(9):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the treatment of dopamine extravasation-induced injury by lidocaine combining dexamethasone. Methods Animal models of dopamine extravasation-induced injury were made using 24 limbs of 6 white mice. These models were divided into 4 groups and given different treatments. Group A was treated with lidocaine combining dexamethasone, group B with lidocaine, group C with normal saline and group D was set as control. The treatment effect was observed. Results The disappearance time of edema in group A was the shortest among the 4 groups and was significantly shorter than that of group C,P＜0.05.Moreover, the pathological changes degree of local tissues in group A were also obviously lower than those of group B,C and D. Conclusion Measures must be taken timely to cope with dopamine extravasation-induced injury. Treatment with lidocaine combining dexamethasone proved to be a prompt, simple and safe method.
