Assessment of risk factors for acute lower-limb deep venous thrombosis
- VernacularTitle:急性下肢深静脉血栓形成危险因素的评估
- Author:
Xiaoping ZHANG
;
Yu HU
;
Bi JIN
;
Deying HU
;
Wenning WEI
;
Shanjun SONG
;
Huafang WANG
- Publication Type:Journal Article
- Keywords:
Venous thrombosis;
Risk factors;
Fibrinogen;
D-dimer
- From:
Chinese Journal of General Surgery
2008;23(3):168-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of coagulation function in patients with acute lowerlimb deep venous thrombosis(DVT)and evaluate the risk factors for DVT. Methods Plasma APTT.PT,TT,D-dimer and fibrinogen(Fbg)were detected by an automated coagulation analyzer in 62 acute lower-limb DVT patients and 70 controls:Retrospective studies on the clinical data of all patients were done by binary logistic regression analysis.Results (1)In DVT group,plasma APTT,PT and TT,the levels of D-dimer and fibrinogen.and D-dimer/fibrinogen ratio(D/F ratio)were higher when compared with control group(au P＜0.01);(2)There were positive correlations between D-dimer and fibrinogen both in DVT and control groups(r=0.475,P＜0.01;r=0.564,P＜0.01,respectively);(3)Logistic analysis indicated that acute lower-limb DVT was associated with the presence of hypertension and increased plasma level of fibrinogen(OR=24.99,P＜0.01: OR=4.346.P＜0.01,respectively).Conclusions Hypertension and elevated plasma level of fibrinogen are independent risk factors for acute lower-limb DVT.
