Effect of Xiaoyuhuatan decoction on insulin resistance of nonalchoholic fatty liver disease rat
- VernacularTitle:消瘀化痰饮对非酒精性脂肪肝大鼠胰岛素抵抗的影响
- Author:
Xiangrui LIU
;
Yixin ZHANG
;
Hui MIAO
;
Cuiping WEI
;
Hua ZHOU
;
Zai WU
- Publication Type:Journal Article
- Keywords:
Xiaoyuhuatan Decoction;
Nonalchoholic fatty liver disease;
Insulin resistance
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(2):190-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective By observing the effect of Xiaoyuhuatan decoction on insulin resistance in rar with nonalchoholic fatty liver,the author made a reasearch into this herb'S machanism on cambating on nonalchoholic fatty liver.Methods The insulin resistance rat model was fed by high fat forage and Dongbaogantai control group was set up for the sake of comparion.We determined the contents of total cholesterol(TC),triglyceride(TG),free fatty acid(FFA),fasting plasma glucose(FBG),fasting serum insulin(INS)in serum and the contents of TC,TG of liver tissue homogenate of each group,and the degree of hepatocytic steatosis.Results Xiaoyuhuatan decoction could obviously decrease the index of insulin resistance and improve insulin insensitive index.Lipid in blood serum and hepatic tissues were significantly decreased,liver fat cell denaturation was improved.Conclusion The thrapentic eftect of Xiaoyuhuatan Decoction on fatty liver is probably contribute tO this herb's mechanism of improving insulin resistance and increasing insulin insensitive.
