The quality of life in man after treatment of advanced prostate cancer by surgical castration
- VernacularTitle:手术去势对晚期前列腺癌患者生活质量的影响
- Author:
Wei CHEN
;
Zhixian YU
;
Hui XIE
;
Fangyi ZHANG
;
Siqi WANG
;
Zhexian DENG
;
Xiuling WU
;
Zhiliang WENG
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Quality of life;
Surgical castration
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(11):20-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the quality of life in man after treatment of advanced prostate cancer by surgical castration. Methods A total of 69 patients with advanced prostate cancer treated by sur-gical castration completed the European organization for research and treatment of cancer quality of life questionnaire (QLQ-C30) and QLQ-prostate specific 25-item (PR25) module third at a 12-month interval.The assessment points were preoporative,6 months postoperative and 12 months postoperative. Results Although there were improvement on pain relief (P ＜ 0.01 ) and symptom of urinary (P ＜ 0.01 ) and global health (P ＜ 0.01 ), the physical functioning (P ＜ 0.05 ), role functioning (P ＜ 0.01 ), emotional functioning (P ＜ 0.01 ), cognitive functioning (P ＜ 0.05 ), social functioning (P ＜ 0.05 or ＜ 0.01 ) were found significantly reduced , and insomnia (P ＜ 0.05) and fatigue (P ＜ 0.01 ) aggravated, treatment related symptoms (P ＜0.01 )appeared predominantly, especially deprivation of sexual functioning. Conclusion The surgical cas-tration when treating advanced prostate cancer did appear to impair the physical and psychological of patients, especially the sexual functioning.
