Proton magnetic resonance spectroscopy on the precentral gyrus of patients with amyotrophic lateral sclerosis
- VernacularTitle:中央前回质子磁共振波谱在肌萎缩侧索硬化患者临床病情评估中的价值
- Author:
Huifang WANG
;
Dongsheng FAN
;
Ning LANG
;
Jun ZHANG
;
Dexuan KANG
;
Liping WANG
;
Xiaoxuan LIU
;
Yu FU
;
Yuanjin ZHANG
;
Hongbin HAN
- Publication Type:Journal Article
- Keywords:
Amyotrophic lateral sclerosis;
Magnetic resonance spectroscopy;
Cerebral cortex
- From:
Chinese Journal of Neurology
2008;41(1):8-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of proton magnetic resonance spectroscopy(1H- MRS)in patients with amyotrophic lateral sclerosis(ALS).Methods Single-voxel1 H-MRS was carried on the preeentral gyri in 110 patients with ALS and 24 patients with lower motor neuron syndrome (LMNS) compared with 89 healthy controls.The upper motor neuron involvement of the patients was assessed by upper motor neuron(UMN)signs and the reflex scale,and the disease severity was evaluated by the AIJS function rating scale(ALS-FRS)and APPEL ALS rate scale(AARS).Results Compared with the healthy controls(1.62±0.18),the NAA/Cr of patients with ALS(1.40±0.25)remarkably decreased (t= -5.007,P=0.000),however,it did not change in patients with LMNS(1.60±0.17)as compared with that of the controls.The NAA/Cr of patients with ALS was also lower than that of patients with LMNS(t= -2.660,P=0.009).Furthermore,the NAA/Cr of patients with definite ALS was lower than those of patients with probable and possible ALS(definite vs probable:t=-2.626,P=0.010;definite vs possible: t=-2.537,P=0.013).On the other hand,patients with pronounced UMN signs had a lower NAA/Cr ratio than those with probable UMN signs(t=-2.827,P=0.006).In patients with asymmetric clinical presentation,the NAA/Cr ratio was significantly lower in the precentral gyrus contralateral to the clinically predominantly affected side(t=-2.652,P=0.011).The NAA/Cr was correlated with the reflex scale scores,ALS-FRS score,and AARS and its sub-items(P＜0.05). Conclusions 1H-MRS is useful in studying ALS.The marker NAA/Cr of precentral gyrus may reflect the UMN degeneration in ALS,which is related to the disease severity and progression.However,it might not be helpful in the early diagnosis and differential diagnosis of the disease.
