Prenatal screening and diagnosis of fetal abnormal chromosome and nervous tube defect: report of 7698 cases
- VernacularTitle:胎儿染色体异常和神经管缺陷的产前筛查与诊断7698例分析
- Author:
Ruiping HUANG
;
Hong ZHOU
;
Zhiying DI
;
Yaying ZHANG
;
Dacheng SUN
- Publication Type:Journal Article
- Keywords:
Prenatal diagnosis;
Pregnancy outcome
- From:
Chinese Journal of General Practitioners
2008;7(1):65-67
- CountryChina
- Language:Chinese
-
Abstract:
This study was to explore the value of maternal serum screen in identification of fetal abnormal chromosome and neural tube defect(NTD). By using time-distinguished fluorescence immunoassay, serum levels of free-β-HCG and alpha fetal protein(AFP)were obtained in 7698 pregnant women at 15～20 +6weeks. and 483 were found at a higher risk of fetal abnormal chromosome. Based on amniotic fluid examination or cord blood testing on 344 high. Risk participants. Fetal abnormal chromosome was found in 18 women with a positive rate of 5. 2%. Twenty-five pregnant women were NTD high-risk, and their positive rate was 0. 3%. B-mode ultrasound identified 6 fetal malformations and 2 fetal deaths ( positive rate of 32. 0%). In high-risk or low-risk group, there were 25. 6%and 7. 7%subjects developed adverse outcome, respectively(P＜0. 05). Our findings suggested that maternal serum screen is an effective prediction factor for fetal abnormal chromosome and NTD.
