Recent memory consequences of drug-resistant medial temporal lobe epilepsy and MRI-positive hippocampns
- VernacularTitle:头颅MRI海马像异常与难治性内侧颞叶癫(癎)患者近期记忆损害
- Author:
Bingwei PENG
;
Liwen WU
;
Yan CHEN
;
Qiong MENG
;
Feng FENG
;
Yan HUANG
- Publication Type:Journal Article
- Keywords:
Epilepsy,temporal lobe;
Memory;
Magnetic resonance imaging
- From:
Chinese Journal of Neurology
2008;41(1):37-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effects of MRI-positive and interictal epileptic charges(IEDs) dominance on the memory of the patients with drug-resistant medial temporal lobe epilepsy (MTLE). Methods Fifty right-handed patients(age ranging from 16 to 60 years old)diagnosed as drug-resistant MTLE in our hospital with normal intelligence between September 2006 and April 2007 were investigated. All patients were classified as left MRI-positive(MRI(+)),right MRI(+),MRI(-),bilateral MR[ (+)by high-quality MR[protocol.The EEG was defined as dominant IEDs if≥75%independent IEDs was confined to one temporal lobe in all EEG recordings.Clinical memory scale was administered as memory assessment of MTLE.ANOVA and non-parametric statistics were used to analyze the data in SPSS 12.0. Results The distribution of age,sex,education,occupation,living condition,course,seizure and treat among left MRI(+),right MRI(+),MRI(-),bilateral MRI(+)groups was similar.All scores in the patients with MTLE was significantly lower than normal(P＜0.05).Right MRI(+)MTLE patients had deftcits in nonsense graphics recognition(9.42±7.46)compared to left MRI(+)and MRI(-) groups((16.26±4.43)and(18.26±5.49),F=4.281,P＜0.05).Among MRI(-)patients,left IEDs,right IEDs and bilateral IEDs groups displayed not significantly different impairment in memory. Conclusion Right MRI(+)MTLE has more severe impairment in non-verbal memory,and nonsense graphics recognition can be used to detect the deficit.
