The detection and analysis of antinuclear antibodies in systemic sclerosis
- VernacularTitle:58例系统性硬皮病抗核抗体谱的检测意义
- Author:
Liqun HUANG
;
Linjian KE
;
Gaozhe ZHEN
- Publication Type:Journal Article
- Keywords:
Systemic sclerosis;
Antinuclear antibodies;
Immunoblot
- From:
Chinese Journal of Postgraduates of Medicine
2007;30(z2):12-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate ANA and ANAs as a indacation of systemic sclerosis diagnostic.Method ANAs were tested in 58 patients with SSc and 20 healthy controls by indirect immunofluorescence (ⅡF)and immunoblot(IB).Results ⅡF-ANA results indicated that the positive of ANAs were 98.3%(57/58)in SSc,and ANA pattern were mainly homogeneous-nucleolar,IB-ENA results indicated that the antinuclear antibodies were mainly anti-Scl-70.anti-SSA and anti-nRNP in SSc.The positive of them were 63.8%、31.O%and 5.2%.Conclusions It suggested that the patients might have other autoimmune diseases or the dangerous of other autoimmune diseases,and the IB kits of euroimmun got better positives and specificities to ANAs,the method could provide more helps to diagnosis of SSc.
