Clinical significance of CA19-9 and CEA detection in diagnosis of pancreatic carcinoma
- VernacularTitle:血清CA19-9和CEA检测在胰腺癌诊断中的价值
- Author:
Qingyong MA
;
Zhenhua MA
;
Zheng WANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
CA19-9;
CEA;
AFP
- From:
Chinese Journal of Hepatobiliary Surgery
2008;14(3):161-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of CA19-9 and CEA detection in the diagnosis of pancreatic carcinoma.Methods From January 2003 to November 2005,serum tumor markers(CA19-9 and CEA)in 44 patients with pancreatic carcinoma and 64 healthy volunteers were detected by radioimmunoassay.Results The levels of CA19-9 and CEA were markedly higher in the patients with pancreatic carcinoma than in healthy volunteers(P＜0.01).The sensitivity of combined detection of CA19-9 and CEA was much higher than any single detection.While the specificity of combined detection of CA19-9 and CEA had no statistical difference when compared to a single detection.The levels of CA19-9 and CEA in the Ⅰ+ⅡA stage patients were of no significant difference as compared with those in the patients of ⅡB+Ⅲ+Ⅳ stage,whereas the sensitivity of CA19-9 and CEA in the patients of ⅡB+Ⅲ+Ⅳ stage but much higher than in those of Ⅰ+ⅡA stage.Conclusion The serum concentrations of CA19-9 and CEA are closely related to pancreatic carcinoma with the invasion of mesenteric artery and lymphatic and distant organic metastasis.Combined detection of CA19-9 and CEA can improve the diagnosis of pancreatic carcinoma.
