Bone marrow-derived mesenchymal stem cells in treatment of gliomas

VernacularTitle:骨髓间充质干细胞在胶质瘤研究中的应用
Author: Youcheng QIU ; Jianyong XU ; Cunzu WANG
Publication Type:Journal Article
Keywords: Mesenchymal stem cells; Gliomas; Gene therapy; Vehicle
From: Journal of International Oncology 2011;38(1):24-26
CountryChina
Language:Chinese
Abstract: Bone marrow-derived mesenchymal stem cells (MSCs) are capable of migrating and homing to brain tumors in vivo and therefore is a promising targeted-delivery vehicle in cancer gene therapy. MSCs are transfected or transducted with the therapeutic genes and achieve stable expression in vitro, then are delivered to the host to exert their therapeutic effects. The Ex Vivo gene transfer of MSCs has been studied in several types of tumors including gliomas, and results were postive. The safety of MSC-based gene delivery remains to be controversial. The interactions between MSCs and host tumor cells need to be investigated.