The expression of membrane type 1 matrix metalloproteinase in the esophageal carcinoma tissues and its clinical significance
- VernacularTitle:膜型基质金属蛋白酶-1在食管癌组织中的表达及其临床意义
- Author:
Xuguang RAO
;
Limin MA
;
Bailiang CHEN
;
Wei YANG
;
Mingke DUAN
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Matrix metalloproteinases,membrane-associated;
Immuno-histochemistry
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(11):25-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of membrane type 1 matrix metalloproteinase(MT1-MMP) in the esophageal carcinoma tissues and in normal periearcinomatous tissues and its clinical significance. Methods Immunohistochemistry was used to study the expression of MT1-MMP in esophageal carcinoma tissues and normal tissues in distance for 5-7 em from tumor. Results Among 54esophageal carcinoma specimens, the positive expression rate of MT1-MMP was 87.0%, while all of themwere expressed a small quantity in normal esophageal epithelial tissues, the expression in the esophageal carcinoma tissues was significantly higher than those in normal esophageal epithelial tissues (P ＜ 0.01 ).The degree of MT1-MMP expressions was associated with the depth of tumor invasion (P ＜ 0.01 ), the invasion of the lymph nodes(P ＜ 0.01 ) and the relapse and/or metastasis of the tumors for three years after surgery(P ＜0.01 ), and was also related to differentiation of tumor cells (P ＜ 0.01 ). Conclusions The expression of MT1-MMP in the esophageal carcinoma tissues is well associated with the depth of tumor invasion, the invasion of the lymph nodes, the differentiation of tumor cells and relapse and/or metastasis of the tumors for three years after surgery. MT1-MMP plays an important rote in the invasion and metastasis in the patients with esophageal carcinoma.
