Association between polymorphisms in HLA-Ⅱ genes and multiple sclerosis in Guizhou Province
- VernacularTitle:HLA-Ⅱ基因多态与贵州地区多发性硬化患者遗传易患性
- Author:
Jin LIANG
;
Lan CHU
;
Zhu XU
;
Liufu ZHANG
;
Xin CAO
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
Histocompatibility antigens class Ⅱ;
Polymorphism,genetic;
Grenetic predisposition to disease
- From:
Chinese Journal of Neurology
2008;41(2):83-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discussed the relationship between multiple sclerosis(MS)and the genepolymorphism of HLA hoping that these results would be useful for further pathogeny studies,diagnoses,therapy and prognosis estimation of MS.Methods HLA-Ⅱ alleles in 32 patients with MS,36 nonimmunological neurological disease controls and 30 healthy controls,were identified by polymerase chain reaction-specific sequence primers(PCR-SSP)methods.Results The gene frequency of HLA-DR16 (7/32,1/36,0/30),DR11(7/32,3/36,1/30)and DQB1*0502(10/32,6/36,4/30)in patients with MS were higher than those in the 2 control groups.The gene frequency of DQB1*0601(8/32,12/36,17/30)in the patients with MS was lower than the controls.However,only the HLA-DR16 had significant difference (χ2=7.398,RR=17.94,P=0.011;χ2=5.52,RR=9.8,P=0.022).Conclusion HLA-DR16 alleles may be associated with the susceptibility to MS in Guizhou Province.
