Correlation between NAD(P)H oxidase p22phox C242T polymorphism and carotid atherosclerosis

VernacularTitle:NAD(P)H氧化酶p22phox亚基C242T基因多态与颈动脉粥样硬化
Author: Chen ZHANG ; Yuqiang SONG ; Xiaolan ZHANG
Publication Type:Journal Article
Keywords: Carotid artery diseases; NADPH oxidase; Polymorphism,restriction fragment length
From: Chinese Journal of Neurology 2008;41(1):25-28
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between NAD(P)H oxidase p22phox C242T polymorphism and carotid atherosclerosis(CA)in Chinese population.Methods 138 patients with CA and 130 control subjects were recruited.C242T polymorphism of p22 phox was analyzed by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP)for determination of its genotype. Results The CT genotype frequencies in the CA group and control group were 0.268 and 0.139, respectively,and no TF genotype was found.The CT genotype frequency of the CA group was significantly higher than that of the control group(X2=6.899,P=0.009).It was found that systolic blood pressure, blood glucose,low density lipoprotein cholesterol smoking and the NAD(P)H oxidase p22 phox C242T polymorphism were independent risk factors for CA by Logistic regression analysis.Conclusions The NAD(P)H oxidase p22 phox C242T polymorphism may be a risk factor for CA.