Impacts of short-term continuous subcutaneous insulin infusion on insulin secretion and sensitivity in newly-diagnosed type 2 diabetes
- VernacularTitle:短期胰岛素泵强化治疗对新诊断2型糖尿病患者胰岛素分泌和敏感性的影响
- Author:
Zhaojun YANG
;
Bo ZHANG
;
Yanyan CHEN
;
Yao WANG
;
Xin WANG
;
Fang ZHAO
;
Guangwei LI
- Publication Type:Journal Article
- Keywords:
Hyperinsulinemia euglycemia clamp technique;
Continuous subcutaneous insulin infusion;
Diabetes mellitus;
type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(2):126-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impacts of short-term continuous subcutaneous insulin infusion (CSII) therapy on insulin secretion and sensitivity in newly-diagnosed type 2 diabetes. Methods Ten patients(7 males, 3 females) with newly-diagnosed type 2 diabetes accepted a 2-week course of intensive CSII therapy during June 2006 and February 2007. Hyperinsulinemia euglycemia clamp test and intravenous glucose tolerance test (IVGTT) were performed before and after CSII. Results (1) None of the patients had acute insulin response (AIR) before CSII treatment, and most of them had a partial restoration after 2-week intensive therapy. The AIR after CSII was significantly increased [(7.63±4.73 vs 0.83±1.96)mU/L, P＜0.01]. The patients whose AIR restored better tend to be younger and obeser. (2) The glucose infusion rate (GIR) before CSII in the newly-diagnosed type 2 diabetic patients was significantly lower than that in healthy controls [(2.30±0.81 vs after 2-week CSII therapy (P＜0.01). The patients whose GIR increased greatly had significantly lower waist circumferences and body mass index, and higher basal blood glucose levels. Conclusion Normalization of blood glucose levels by transient intensive CSII therapy improves pancreas β-cell function and insulin sensitivity, which seems to contribute to the long-term diabetic remission.
