Variation and influential factors of high sensitive C-reactive protein level in type 2 diabetic family members
- VernacularTitle:2型糖尿病家系成员血清高敏C反应蛋白水平变化及影响因素
- Author:
Song LIANG
;
Wei REN
;
Suhua ZHANG
;
Xiaoli WAN
;
Lilin GONG
;
Xiaosu BAI
;
Ruizhi ZHENG
;
Maorong WANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
type 2;
First-degree relatives;
C-reactive protein
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(2):153-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the variation and influential factors of high sensitive C-reactive protein (hs-CRP) level in type 2 diabetic family members. Methods A total of 427 type 2 diabetic patients, 377 non-diabetic first-degree relatives of type 2 diabetics and 135 normal control subjects without diabetic family history were recruited. Serum hs-CRP, clinical and biochemical parameters were measured. The relations among indicators were analyzed. Results Compared with normal control subjects, serum hs-CRP levels in type 2 diabetics and first-degree relatives were significantly increased (both P＜0.05), and the increment was even marked in type 2 diabetics than that in first-degree relatives (P＜0.01). The serum hs-CRP levels in type 2 diabetics and first-degree relatives were positively associated with body mass index, waist-hip ratio, abdominal circumference, postgrandial 2 h plasma glucose, fasting and postgrandial 2 h serum insulin, HOMA-IR, triglyceride, creatinine and negatively correlated with high density lipoprotein-cholesterol. In first-degree relatives, serum hs-CRP level was positively associated with systolic blood pressure and HOMA-β. Conclusion As in type 2 diabetic patients, there exists inflammatory reaction in the non-diabetic first-degree relatives of type 2 diabetics, which may play an important role in the pathogenesis of type 2 diabetes mellitus.
