Effect of desogestrel and ethinyl estradiol pretreatment in superovulation cycles with short protocol
- VernacularTitle:去氧孕烯-炔雌醇预治疗在短方案促排卵周期中的应用
- Author:
Junzhao ZHAO
;
Xianhua LIN
;
Xuefeng HUANG
;
Jinju LIN
;
Wenqin LIN
;
Bilü YE
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Embryo transfer;
Ovulation induction;
Clinical protocols;
Desogestrel;
Contraceptives,oral
- From:
Chinese Journal of Obstetrics and Gynecology
2008;43(2):102-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prevalence of nonalcoholic fatty liver disease(NAFLD)in patients with polycystic ovary syndrome(PCOS).MethodsA case-control study employing 60 non pregnant patients with PCOS and 60 non-pregnant patients without PCOS as control was conducted to compare the prevalence of NAFLD.Resuits The aminotransferase(ALT),fasting insulin and homeostasis model assessment of insulin resistance(HOMA-IR)levels were(29±15)U/L,(19±12)mU/L and 0.47±0.29 in PCOS group,which were significantly higher(P＜0.05)than corresponding parameters in control group[(15±13)U/L,(11±8)mU/L and 0.31±0.21)].The occurrence of insulin resistance and NAFLD was 63％(38/60)and 42％(25/60),higher than those in control group[35％(21/60)and 20％(12/60),P＜0.05].The increment of ALT was 40％(24/60)in PCOS group,higher than that of 3％(2/60)in control group(P＜0.01).Compared with patients witIlout NAFLD,patients with NAFLD had significantly increased body mass index(P＜0.01),waist-hip ratio,AIJT,C-reaction protein,fasting insulin,insulin and HOMA-IR levels 2 hours after oral glucose tolerance test(P＜0.05).Conchsion The increased prevalence of NAFLD in PCOS patients suggests an association between these two conditions and the necessity of hepatic screening among PCOS patients for potential NAFLD.
