A preliminary functional MRI study with temporal clustering analysis fof localization of epileptic activity
- VernacularTitle:时间聚类分析功能MRI对癫痫病灶定位的初步研究
- Author:
Junpeng WANG
;
Guangming LU
;
Zhiqiang ZHANG
;
Yuan ZHONG
;
Xueman JI
;
Ling ZHENG
;
Jiahong GAO
;
Yijun LIU
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Epilepsy
- From:
Chinese Journal of Radiology
2008;42(2):162-166
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the potential of using temporal clustering analysis(TCA)technique in localizing an epileptogenic zone.MethodsTwelve patients with epilepsy were examined using resting functional MRI(fMRI). The patients had detectable focal lesions on cranial MRI.TCA was performed to analyze resting fMRI data in order to identify the timing of interictal epileptiform discharges (IEDs).Standard event-related fMRI analysis in SPM99 was used to generate maps of the activation induced by epileptic brain activities.Comparisons were made between TCA Resultsand SPM motion trochoid.ResultsEight of the twelve subiects showed activations in the brain regions that were consistent with those lesions determined on anatomic MRI.The remaining four subiects showed no clear activation in the areas of detectable lesions. In addition, correlation was found between TCA Resultsand motion trochoids.ConclusionsTemporal cluster analysis,an exploratory data-driven technique,may provide the timing information about interictal epileptiforill discharges.However,the Resultsfrom this novel fMRI analytical technique need to be interpreted with caution as it is vulnerable to motion artifact.
