Therapy effect of melatonin and hypothermia on hypoxic-ischemic brain damage
10.3760/cma.j.issn.1673-4408.2011.02.003
- VernacularTitle:褪黑素和亚低温对新生儿缺氧缺血性脑损伤的治疗作用
- Author:
Lili QIAO
- Publication Type:Journal Article
- Keywords:
Melatonin;
Hypothermia;
Newborn;
Hypoxic-ischemic brain damage
- From:
International Journal of Pediatrics
2011;38(2):105-107
- CountryChina
- Language:Chinese
-
Abstract:
Melatonin has neuroprotective effect on hypoxic-ischemic brain damage(HIBD), which easily crosses the blood-brain barrier and plays neuroprotective role in reducing oxidative damage. Melatonin may be effective in preventing learing diabilities. It has been suggested that melatonin soporific effect is secondary to its ability to induce hypothermia. Neuroprotective effect of hypothmia has been proved. Howere, it is clear that hypothemia will not provide complete protection of HIBD and melatonin might augment protection of hypothemia in HIBD.
