CTLA-4 gene 49 A/G polymorphism is associated with relapse of Graves′ disease
- VernacularTitle:CTLA-4基因49A/G多态性与Graves病复发相关
- Author:
Jingling ZHANG
;
Shengli YAN
- Publication Type:Journal Article
- Keywords:
Graves′ disease;
Recurrence;
Cytotoxic T lymphocyte associated antigen 4;
Polymorphism;
single nucleotide
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(2):192-193
- CountryChina
- Language:Chinese
-
Abstract:
The A/G polymorphism of cytotoxic T lymphocyte associated antiger 4(CTLA-4) was determined by PCR-RFLP in 120 patients with recurrent Graves′ disease (GD), including 85 cases with early relapses within 3 years and 35 cases with relapses more than 3 years after withdrawal of antithyroid medication.66 initial GD patients and 100 healthy controls were included in the present study.The results suggest that A/G polymorphism of CTLA-4 was associated not only with GD, but also with early relapes after withdrawal of antithyroid medication.
