Expression of COX-2,VEGF-C and lymphatic vessel density in pancreatic cancer
- VernacularTitle:胰腺癌组织中COX-2、VEGF-C表达和淋巴管密度
- Author:
Xueguo SUN
;
Qingxi ZHAO
;
Zibin TIAN
;
Cuiping ZHANG
;
Shun ZHANG
;
Yujun LI
;
Xinjuan KONG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Cyclooxygenase 2;
Vascalar endothelial growth factor C;
VEGFR-3;
Lymphangiogenesis;
Lymphatic vessel density
- From:
Chinese Journal of Pancreatology
2008;8(2):108-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detecte the expression of COX-2,VEGF-C and lymphatic vessel density (LVD)in pancreatic cancerous and paracancerous tissues,and investigate their correlation.Methods The expression of COX-2.VEGF-C and LVD in 40 cases of pancreatic cancer tissues and paracancerous tissues and 12 cases of normal pancreas was detected by tissue chip and immunohistochemical assays,and the relationship between them and the cljnicopathological parameters was analyzed. Results The expression of COX-2,VEGF-C in pancreatic cancer tissues were 70.0%(28/40)and 67.5%(27/40),respectively,which were significantly higher than that in paracancerous tissues(42.5%,17/40)and(35.0%,14/40),and that in normal pancreas(8.3%,1/12)and(25.0%,3/12).The LVD in pancreatic cancerous,paracancerous and normal pancreatic tissues were 4.75±2.77,15.2 ±4.70 and 1.67±1.15,respectively.The expression of COX-2 in cancerous tissues and LVD in paracancerous tissues was correlated with tumor differentiation and lymph metastasis;the expression of VEGF-C Was correlated with lymph metastasis.LVD in paracancerous tissues was correlated with the expression of COX-2 and VEGF-C.Conclusions Pancreatic cancer lymphangiogenesis mainly existed in paracancerous tissues,COX-2 and VEGF-C may play an important role in the lymphangiogenesis.
