Expressions of CD26,Ki67 and EGFR proteins in primany thyroid neoplasms and their value in differential diagnosis
- VernacularTitle:CD26、Ki67和表皮生长因子受体在甲状腺肿瘤中的表达及其诊断意义
- Author:
Lizhi SHANG
;
Yuming YANG
;
Dexiang LI
;
Dawen WEI
;
Xiaoju CHENG
- Publication Type:Journal Article
- Keywords:
Antigens;
CD26;
Ki-67 antigen;
Epidermal growth factor receptor;
Thyroid neoplasms;
Diagnosis;
differential
- From:
Chinese Journal of Endocrinology and Metabolism
2008;24(2):174-177
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expressions of CD26, Ki67 and epidermal growth factor receptor(EGFR) proteins in thyroid neoplasms, to explore their value in differential diagnosis between benign and malignant thyroid neoplasms and to search for molecular marker in well-differentiated thyroid carcinomas.Methods The expressions of CD26,Ki67and EGFR proteins were examined by immunohistochemistry in 50 differentiated thyroid carcinomas (TC) and 50 thyroid adenomas (TA) and their relationships were analyzed.Results The positive rate and expression intensity of CD26,Ki67and EGFR proteins in TC were significantly higher than those in TA, and especially higher in follicular TC than those in follicular TA.Conclusion The abnormal expressions of CD26, Ki67and EGFR proteins appear to be valuable in differential diagnosis and predicting prognosis of thyroid carcinomas, especially CD26 can be used as a diagnostic marker in well-differentiated carcinoma of follicular cell origin.
