Telomere,telomerase,cell of immortalization and aging
- VernacularTitle:端粒、端粒酶与细胞衰老及永生化
- Author:
Yong TENG
;
Yunyu HU
;
Yucheng GUAN
- Publication Type:Journal Article
- Keywords:
Telomerase;
Human telomerase catalytic subunit;
Aging;
Tissue engineering
- From:
International Journal of Biomedical Engineering
2008;31(2):106-109
- CountryChina
- Language:Chinese
-
Abstract:
Normal cells have limited proliferation ability.After certain cycles of proliferation,they will lose the response ability to growth factors and finally cease division and start the course of aging. In current opinion,lacking of the terminal end of a chromosome(telomere)is the cause for cells to loss the proliferation ability and leads cells to aging and death.The human telomerase catalytic subunit 1(hTERT)can activate telomemse which prolong DNAs of the terminal end of chmmosome and help cells gain genomic stabilization.The discoveries of telomere,telomerase and hTERT provide new idea for studying of cell aging and the findings are also applied in the establishment of immortal cell line. Also they may play an important role in the studv of biological feature of seed cell in tissue engineering and the establishment of cell bank.
