Distribufion and significance of IgG subclasses of serum antithyroglobulin antibody in Hashimoto thyroiditis
- VernacularTitle:甲状腺球蛋白抗体IgG亚型在桥本甲状腺炎中的分布及意义
- Author:
Maorong LI
;
Xiaohui GUO
;
Ying GAO
;
Yanming GAO
;
Guizhi LU
;
Yan HUI
;
Shufeng WANG
;
Bingyin SHI
;
Weiping TENG
- Publication Type:Journal Article
- Keywords:
Thyroiditis,autoimmune;
Thyroglobulin;
Antibodies;
Immunoglobulins
- From:
Chinese Journal of Internal Medicine
2008;47(2):121-124
- CountryChina
- Language:Chinese
-
Abstract:
objective To evaluate the distribution and significance of IgG subclasses of antithyroglobulin antibody in sera from patients with Hashimoto thyroiditis.Methods Sera from 112 patients with Hashimoto thyroiditis were collected and patients were divided into 3 groups,i.e.hypothyroidism,subclinical hypothyroidism and euthyroidism.Antigen specific ELISA was used to detect the distribution of IgG subclasses of antithyroglobulin antibody.Results The positive rates of IgG subclasses of TgAb were IgG1 90.2%,IgG2 58.0%,IgG3 19.6%and IgG4 87.5%respectively.The mean geometric titers of IgG1 in sera from patients with hypothyroidism and subclinical hypothyroidism were 1:450.8 and 1:245.5 respectively,both being significantly higher than that with euthyroidism(1:8.7,P＜0.01).The mean geometric titers of IgG2 in sera from patients with hypothyroidism and subclinical hypothyroidism were 1:37.3 and 1:3.2 respectively,both being also significantly higher than that with euthyroidism(1:0.2,P＜0.01 and P＜0.05 respectively)and that with hypothyroidism was significantly higher than that with subclinical hypothyroidism(P＜0.05).Conclusion The distribution of IgG subclasses of antithyroglobulin antibody in sera from patients with Hashimoto thyroiditis was predominantly IgG1,IgG2 and IgG4.High titers of IgG1 and IgG2 implicated the possibility of development from subclinical hypothyroidism to overt hypothyroidism.
