Progress in research of long-term potentiation on brain slice
- VernacularTitle:在脑片水平上突触可塑性长时程增强的研究进展
- Author:
Xiaobo ZHENG
;
Xin TIAN
;
Yijun SONG
- Publication Type:Journal Article
- Keywords:
Brain slice;
Synaptic plasticity;
Long-term potentiation;
Synaptic efficacy
- From:
International Journal of Biomedical Engineering
2008;31(2):85-89
- CountryChina
- Language:Chinese
-
Abstract:
Long-term potentiation(LTP)is an important form of synaptic plasticity and an objective indicator to investigate learing and memory synaptic mechanisms.With the development of brain slice technology,more and more experiments associated with LTP are carried out on brain slices,which aim to investigate the mechanism in biology and the change in physiology or biochemistry are carried out on the brain slice.This paper gives an overview of recent advances in research of LTP with technology of brain sliceby suchexamples as follows:The regulated expression mechanisms of long-term potentiation at CA1 synapses,the characteristics of LTP induced in hippcampal slices and its relation with the slice-recovery conditions,the enhancement of the magnitude of early longterm potentiation at CA1 hippocampal synapse by the activation of dopamine receptor,and the enhancement of associative long-term potentiation by the activation of β-adrenergic receptors at CA1 synapses in rat hippocampol slices.
