Advance in mechanism research of the interaction between bone plant on osteoblast
- VernacularTitle:成骨细胞与纳米植入材料相互作用研究进展
- Author:
Weiping JI
;
Pei HAN
;
Yao JIANG
- Publication Type:Journal Article
- Keywords:
Nano metre;
Extracellular matrix;
Cytoskeletal proteins;
Osteoblast;
Mechanism
- From:
International Journal of Biomedical Engineering
2008;31(2):115-119
- CountryChina
- Language:Chinese
-
Abstract:
The conformity between bone implant and bone tissue plays an important role in osseointegration.Protein molecules such as extracellular matrix proteins,cytoskeletal proteins,and attachment proteins,which produced by osteoblasts,promote the attachment of osteoblasts to bone implant and the surrounding ceils.In vitro studies show that nano-plated implant material bears excellent biocompatibility and superior physical and chemical features.Nano-scale material has the advantage of high surface roughness,wettability and electrochemistry features which erdaance the adherence and interaction of extracellular matrix proteins and promotes the attachmerit,proliferation and differentiation of osteoblasts.The expression of cytokines,such as prostaglandin E2(PGE2)and transforming growth factor-β(TGF-β)are also increased in nano-structured bone implants which in turn promote the new bone formation.Further studies need to be done to explain the mechanism of the effect of nano-tructured bone implant on osteoblasts.
